Searchable abstracts of presentations at key conferences in endocrinology

ea0099p412 | Adrenal and Cardiovascular Endocrinology | ECE2024

β-estradiol contributes to sex differences in resilience to septic-induced cardiacdysfunction via GPER-1/PPARδ/NLRP3 signaling

Adu-Amankwaah Joseph , Fu Lu , Mprah Richard , Noah Marie Louise Ndzie , Gong Zheng , Sun Hong

Background and aim: Sepsis, a leading global cause of mortality, involves life threatening multi-organ failure triggered by a dysregulated host response to infection. Cardiac dysfunction significantly contributes to this failure, primarily influenced by septic-induced metabolic dysregulation. Clinical studies suggest a less favorable outcome for males in sepsis, potentially linked to hormonal disparities, which remains unclear. This study aimed to explore the sex-related cardi...